Post-doc in Microbiology (M/F)

Ifremer

Ifremer

Nantes, France
Posted 6+ months ago

Job Description

Job title : Post-doc in Microbiology (M/F)

Reference: PV-2023-1338/1

Department/Office:

Duration of contract:18 mois

Start date:

Deadline for applications:06/08/2023

The Institute and the recruiting departement

A pioneer in ocean science, IFREMER’s cutting-edge research is grounded in sustainable development and open science. Our vision is to advance science, expertise and innovation to:

- Protect and restore the ocean

- Sustainably use marine resources to benefit society

- Create and share ocean data, information & knowledge.

With more than 1,500 personnel spread along the French coastline in more than 20 sites, the Institute explores the 3 great oceans: the Indian, Atlantic and Pacific oceans. A leader in ocean science, IFREMER is managing the French Oceanographic Fleet and its dedicated scientists create ground-breaking technology to push the boundaries of ocean exploration and knowledge, from the abyss to the atmosphere-ocean interface.

Well-established in the international scientific community, our scientists, engineers and technicians are committed to advance knowledge about our planet’s last unexplored frontiers. They provide the science we need for informed decision-making and public policy and they transfer this knowledge and technology to businesses to fulfill public and private needs. Core to our mission is also to strengthen public awareness about the importance of understanding the ocean and its resources, and empowering future generations of leaders through education and outreach national campaigns.

Founded in 1984, IFREMER is a French public organization and its budget approximates 240 million euros. It is operating under the joint authority of the French Ministry for Higher Education, Research and Innovation, the french Ministry of the Sea, the French Ministry for the Ecological and Solidary Transition, and the French Ministry of Agriculture and Food.

General areas of responsibility

The objectives of the Microbiology Food Health and Environment (MASAE) unit are to study the diversity and evolution of micro-organisms of anthropogenic or marine origins present in the coastal environment and in foods of marine origin, to understand their effects on the microbiological quality/safety of products derived from them.

The Laboratory Health Environment and Microbiology (LSEM) develops research activities related to pathogenic microorganisms for Humans (mainly viruses and bacteria) in the land-sea continuum and shellfish, to understand the mechanisms of transfer, persistence, or emergence within the coastal environment. The research carried out at LSEM, located at the interface of human health and the microbiological quality of the shoreline, is based on reference activities (the LSEM is the National Reference Laboratory (NRL) for the microbiology of shellfish), and knowledge of the microbiological quality of the coastline (the LSEM coordinates the REMI, a network dedicated to microbiological monitoring of shellfish and health studies).

Placed under the hierarchical responsibility of the LSEM manager, she/he will be in charge of the research project part of the OBEPINE consortium ' study of genomic diversity of hepatitis E virus and norovirus in human sewage and slaughter sewage' set up in collaboration with Nancy university (LCPME).



General areas of responsibility

The research will focus on the analysis of the characteristics of bacterial strains of public health interest (leisure activity or consumption of shellfish): evaluation of the mechanisms related to virulence, pathogenicity, adaptation to niches and persistence in the environment, or antibiotic resistance. In concert with the work developed at the LSEM on the analysis of microbial flora (bacteria and viruses), she/he will help to identify microbiome factors favoring the emergence of bacterial strains pathogenic for Humans in a one-health approach. Thess research activities will contribute to the laboratory’s expertise as part of its NRL missions.



Principal activities

  • Develop efficient methods to concentrate viruses and extract/purify viral nucleic acids, from large volumes of turbid wastewaters.
  • Optimize targeted metagenomics approaches to characterize the genotypes of NoV present in wastewaters. This will require the selection of primer sets to amplify the NoV typing regions, and develop a sensitive method avoiding the formation of chimeras, and preferably quantitative, using artificial samples of known composition, based on previous work of the team. This approach will then be validated using RNA extracted from urban and slaughter house wastewaters, and PCR products sequenced using two NGS platforms, Illumina and Oxford Nanopore technologies. These data will allow to document the diversity of human and porcine strains of NoV circulating in two French regions.



Collaborative work environment

  • Internal collaborative relationship : the laboratory, unit and other microbiologists of the department and institute.

  • External collaborative relationship : members of the LCPME team and other partners of the Obepine network.

Required Knowledge, skills, and characteristics

  • PhD in microbiology ( obtained 3 years ago maximum)
  • Experience on working with human viruses expected



Required knowledge, skills and characteristics

Knowledge, skills and abilities

  • Microbiology (virology) knowledge,
  • Molecular biology, metagenomic
  • Bioinformatics analyses,
  • Writing, project management, and exploitation (publications & congresses)
  • Fluency in English (oral and written),

Personal human qualities

  • Scientific rigour, autonomy, dynamism, curiosity,
  • Sense of responsibility,
  • Sense of relationship, communication and pedagogy,
  • Capacity to work within a research group

Specific working conditions

  • Full time
  • 18 months

How to apply for this position

Deadline for applications: 08/08/2023

All applications are processed exclusively via our website. Interested candidates can apply by clicking the “Apply” button.