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Scientist, Alzheimer's and Neurodegenerative Diseases

[C]Worthy

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Watertown, MA, USA

Posted on Thursday, September 28, 2023

Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians.

Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.

How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org.

PTI’s new approach requires synergy between a diverse team of chemists, machine learning engineers, biologists and mass spectrometrists. Alzheimer’s disease and aging will be among the first focuses of this technology-driven research organization.

New career opportunities

Members of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals.

Responsibilities

Lead biological projects related to proteomics of Alzheimer's disease.
Collaborate with chemists, research associates, computational scientists and mass spectrometrists to leverage PTI's platform for protein barcoding for biological discovery.
Work closely with experimental and computational scientists to collaboratively design experiments, analyze experimental data, and interpret results.
Perform experiments with exceptional levels of competence, reproducibility and documentation following appropriate research practices, including excellent laboratory notebook practices.
Prepare internal reports and manuscripts, and present results at internal or external scientific meetings as appropriate.

Required qualifications

PhD in biology (e.g. Bioengineering, Molecular Biology, Neurobiology) or a related field in science and/or engineering, or equivalent working experience and track record.
Extensive experience with molecular biology laboratory technique, e.g. cell and tissue culture, optical microscopy, molecular cloning, quantitative PCR, immunohistochemistry, etc.
Excellent communication skills, record keeping ability, and attention to detail.
Excellent interpersonal and collaboration skills.

Preferred Qualifications

Strong record of publications in peer-reviewed scientific journals.

Who will love this job

You have a strong desire and intrinsic motivation to work collaboratively and inclusively as part of an interdisciplinary team science effort.
You are committed to the ethos of open science, and want to see your work transparently disseminated.
You’re mission-driven, and are seeking an environment where you can take long-term risks on moonshot science, shielded from academic or for-profit incentives.
You’re seeking a high-leverage, non-traditional opportunity to maximize the impact of your science, establishing relationships with key stakeholders in the neuroscience community.
You understand, appreciate and are ready to tackle the significant experimental challenges related to scalable cellular barcoding of mammalian brains.

We offer

An opportunity to change the world and work with some of the most talented and collaborative experts across scientific fields.
Excellent medical, dental, and vision insurance through a PPO plan; parental leave.
Generous time off + paid holidays.
Wellness allowance for fitness and wellness activities.

The Company aims to help fill a structural gap in today's R&D system. We enable fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We’re bringing together top talent from academia, industry, and startups to build a new model for innovative R&D. As an incubator within the Schmidt Futures Network, we identify high-impact scientific or technical research and development opportunities, ultimately defining and launching these projects as Focused Research Organizations.

The Company is an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or Company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.

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